Randomized, double-blind, placebo-controlled phase II trial of nanocurcumin in prostate cancer patients undergoing radiotherapy. View abstract. View abstract. 1990;29(1):25-34. View abstract. A randomized controlled trial on the anti-inflammatory effects of curcumin in patients with chronic sulphur mustard-induced cutaneous complications. View abstract. Neurosci.Lett. Kang SC, Lee CM, Choi H, et al. DailyMed will deliver notification of updates and additions to Drug Label information currently shown on this site through its RSS feed. 2008;74(11):1374-1379. View abstract. Because the chemicals used in Spice have a high potential for abuse and no medical benefit, the Drug Enforcement Administration has made many of the active chemicals  found in Spice illegal. Babu, P. S. and Srinivasan, K. Influence of dietary curcumin and cholesterol on the progression of experimentally induced diabetes in albino rat. Medications that slow blood clotting (Anticoagulant / Antiplatelet drugs) interacts with TURMERIC. View abstract. View abstract. View abstract. View abstract. Mol.Cell Biochem. View abstract. Panminerva Med 2010;52(2 Suppl 1):55-62. BMC.Pharmacol 2005;5:15. Early research suggests that taking turmeric daily for 4 weeks is less effective than conventional treatment for eliminating certain bacteria (H. pylori) that can cause stomach ulcers. Indian J Med.Res. View abstract. Romero, M. R., Efferth, T., Serrano, M. A., Castano, B., Macias, R. I., Briz, O., and Marin, J. J. Br.J Pharmacol 2003;139(2):209-218. View abstract. Price, R. J., Scott, M. P., Giddings, A. M., Walters, D. G., Stierum, R. H., Meredith, C., and Lake, B. G. Effect of butylated hydroxytoluene, curcumin, propyl gallate and thiabendazole on cytochrome P450 forms in cultured human hepatocytes. 10-14-2009;57(19):9226-9233. Int.J Radiat.Oncol.Biol.Phys. Toxicol Lett. Spice is a new drug… Structure elucidation and NMR assignments for curcuminoids from the rhizomes of Curcuma longa. View abstract. It is often called “synthetic marijuana” or "fake weed" because some of the chemicals in it are similar to ones in marijuana. Antony S, Kuttan R, Kuttan G. Immunomodulatory activity of curcumin. Cancer Lett 2002;175:79-88. View abstract. Panahi Y, Kinpour P, Mohtashami R, Jafari R, Simental-Mendia LE, Sahebkar A. Efficacy and safety of phytosomal curcumin in non-alcoholic fatty liver disease: a randomized controlled trial. Benny, M and Antony B. Bioavailability of Biocurcumax (BCM - 095). Prostaglandins Leukot.Essent.Fatty Acids 1989;37(1):57-64. View abstract. Efficacy and safety of curcumin in treatment of intestinal adenomas in patients with familial adenomatous polyposis. Effects of a turmeric extract (Curcuma longa) on chronic ultraviolet B irradiation-induced skin damage in melanin-possessing hairless mice. Swelling (inflammation) of the eye (uveitis). Magn Reson.Chem. J Med Food. One of the chemicals in ginger is also used as an ingredient in laxative, anti-gas, and antacid medications. View abstract. J Agric.Food Chem. Mechanisms of action Preventing gas. Phytother Res. Cui, L., Miao, J., and Cui, L. Cytotoxic effect of curcumin on malaria parasite Plasmodium falciparum: inhibition of histone acetylation and generation of reactive oxygen species. Curcumin is a powerful antioxidant that also boasts a long list of health benefits. Sivalingam, N., Hanumantharaya, R., Faith, M., Basivireddy, J., Balasubramanian, K. A., and Jacob, M. Curcumin reduces indomethacin-induced damage in the rat small intestine. View abstract. 2016 Jun;25(2):151-7. Sugimoto, K., Hanai, H., Tozawa, K., Aoshi, T., Uchijima, M., Nagata, T., and Koide, Y. Curcumin prevents and ameliorates trinitrobenzene sulfonic acid-induced colitis in mice. Urology 2006;67(2):440-446. Yu, Z. F., Kong, L. D., and Chen, Y. Antidepressant activity of aqueous extracts of Curcuma longa in mice. 2006;290(1-2):87-96. Biol.Chem. View abstract. Ahmed, T., Gilani, A. H., Hosseinmardi, N., Semnanian, S., Enam, S. A., and Fathollahi, Y. Curcuminoids rescue long-term potentiation impaired by amyloid peptide in rat hippocampal slices. Belcaro G, Cesarone MR, Dugall M, et al. 11-16-2005;53(23):9005-9009. Eur J Phys Rehabil Med. Reyes-Gordillo, K., Segovia, J., Shibayama, M., Tsutsumi, V., Vergara, P., Moreno, M. G., and Muriel, P. Curcumin prevents and reverses cirrhosis induced by bile duct obstruction or CCl4 in rats: role of TGF-beta modulation and oxidative stress. 2009;91(1):271-277. Inflammation and damage to the rectum due to radiation therapy. Fung FY, Wong WH, Ang SK, et al. View abstract. Asian J Androl 2004;6(1):71-74. Therapie 2004;59(6):639-644. View abstract. Se.Pu. Curcuminoid content and safety-related markers of quality of turmeric dietary supplements sold in an urban retail marketplace in the United States. Biological activities of Curcuma longa L. Mem Inst Oswaldo Cruz 2001;96:723-8. Ahmed, T., Enam, S. A., and Gilani, A. H. Curcuminoids enhance memory in an amyloid-infused rat model of Alzheimer's disease. 2009;20(4):314-319. Free Radic.Res 2008;42(11-12):999-1005. Int.J Clin Pharmacol Ther.Toxicol. View abstract. 2016;117(6):697-702.e1. Kiec-Swierczynska, M. and Krecisz, B. 2018;10(11). Anti-tumor promoting potential of selected spice ingredients with antioxidative and anti-inflammatory activities: a short review. Imam Z, Khasawneh M, Jomaa D, Iftikhar H, Sayedahmad Z. Regulation of pro-inflammatory cytokine expression by curcumin in hyaline membrane disease (HMD). Takada Y, Bhardwaj A, Potdar P, Aggarwal BB. 1997;166(1-2):169-175. J Pharm Pharmacol 2000;52(4):437-440. Chainani-Wu, N., Madden, E., Lozada-Nur, F., and Silverman S Jr. High-dose curcuminoids are efficacious in the reduction in symptoms and signs of oral lichen planus. 2004;17(4):221-228. Literat, A., Su, F., Norwicki, M., Durand, M., Ramanathan, R., Jones, C. A., Minoo, P., and Kwong, K. Y. Krizkova, J., Burdova, K., Hudecek, J., Stiborova, M., and Hodek, P. Induction of cytochromes P450 in small intestine by chemopreventive compounds. Short-term effects of highly-bioavailable curcumin for treating knee osteoarthritis: a randomized, double-blind, placebo-controlled prospective study. 10-20-1992;221(2-3):381-384. 2008;17(6):1411-1417. Cancer Epidemiol.Biomarkers Prev. 9-21-2007;361(2):528-532. Arthritis Res Ther. But, its effects are sometimes very different from marijuana, and often much stronger. Stress. View abstract. View abstract. View abstract. View abstract. The pill is not for everyone, since oral antifungals can interact with other medications and can affect the liver. View abstract. Weisberg, S. P., Leibel, R., and Tortoriello, D. V. Dietary curcumin significantly improves obesity-associated inflammation and diabetes in mouse models of diabesity. 2009;10(4):293-297. Huang, C. Y., Chen, J. H., Tsai, C. H., Kuo, W. W., Liu, J. Y., and Chang, Y. C. Regulation of extracellular signal-regulated protein kinase signaling in human osteosarcoma cells stimulated with nicotine. J Pharm.Pharmacol 1973;25(6):447-452. Chatterjee, S., Variyar, P. S., and Sharma, A. View abstract. 12-7-2001;70(3):253-267. Flynn, D. L., Rafferty, M. F., and Boctor, A. M. Inhibition of 5-hydroxy-eicosatetraenoic acid (5-HETE) formation in intact human neutrophils by naturally-occurring diarylheptanoids: inhibitory activities of curcuminoids and yakuchinones. Kumar, A., Purwar, B., Shrivastava, A., and Pandey, S. Effects of curcumin on the intestinal motility of albino rats. Cell Biochem.Funct. 2008;46(3):920-928. Mahammedi H, Planchat E, Pouget M, et al. Kizhakkedath R. Clinical evaluation of a formulation containing Curcuma longa and Boswellia serrata extracts in the management of knee osteoarthritis. Kim, K., Kim, K. H., Kim, H. Y., Cho, H. K., Sakamoto, N., and Cheong, J. Curcumin inhibits hepatitis C virus replication via suppressing the Akt-SREBP-1 pathway. View abstract. A grouping of symptoms that increase the risk of diabetes, heart disease, and stroke (metabolic syndrome). B. Antiproliferative effect of curcumin (diferuloylmethane) against human breast tumor cell lines. Baum L, Lam CW, Cheung SK, et al. Chem.Pharm Bull. Lao, C. D., Ruffin, M. T., Normolle, D., Heath, D. D., Murray, S. I., Bailey, J. M., Boggs, M. E., Crowell, J., Rock, C. L., and Brenner, D. E. Dose escalation of a curcuminoid formulation. 2001;29(8):1074-1079. Int.J Radiat.Biol. 2013;15(1):195-218. Srinivasan A, Selvarajan S, Kamalanathan S, Kadhiravan T, Prasanna Lakshmi NC, Adithan S. Effect of Curcuma longa on vascular function in native Tamilians with type 2 diabetes mellitus: A randomized, double-blind, parallel arm, placebo-controlled trial. Int.J Pharm 6-7-2007;337(1-2):169-177. 2008;29(5):717-721. View abstract. High levels of cholesterol or other fats (lipids) in the blood (hyperlipidemia). Rukkumani, R., Aruna, K., Varma, P. S., and Menon, V. P. Curcumin influences hepatic expression patterns of matrix metalloproteinases in liver toxicity. Get the latest information from CDC (coronavirus.gov) | NIH Resources | NIDA Resources, Also known as: Black Mamba, Bliss, Bombay Blue, Fake Weed, Genie, K2, Yucatan Fire, and Zohai, Spice is a mix of herbs (shredded plant material) and laboratory-made chemicals with mind-altering effects. Biochem.Biophys.Res Commun. 10-8-2008;56(19):8787-8792. 2010;56(4):96-101. View abstract. Mrudula, T., Suryanarayana, P., Srinivas, P. N., and Reddy, G. B. Anal.Sci. Suhail FK, Masood U, Sharma A, John S, Dhamoon A. Turmeric supplement induced hepatotoxicity: a rare complication of a poorly regulated substance. Tanwar, V., Sachdeva, J., Kishore, K., Mittal, R., Nag, T. C., Ray, R., Kumari, S., and Arya, D. S. Dose-dependent actions of curcumin in experimentally induced myocardial necrosis: a biochemical, histopathological, and electron microscopic evidence. Complement Ther Med. 2010;9(1):8-14. Deodhar SD, Sethi R, Srimal RC. B., Yao, Q., and Chen, C. Effects of TNF-alpha and curcumin on the expression of thrombomodulin and endothelial protein C receptor in human endothelial cells. View abstract. Wu S, Xiao D. Effect of curcumin on nasal symptoms and airflow in patients with perennial allergic rhinitis. Yeh, C. H., Lin, Y. M., Wu, Y. C., and Lin, P. J. Inhibition of NF-kappa B activation can attenuate ischemia/reperfusion-induced contractility impairment via decreasing cardiomyocytic proinflammatory gene up-regulation and matrix metalloproteinase expression. Prostate 6-1-2001;47(4):293-303. 7. View abstract. Memory and brain amyloid and tau effects of a bioavailable form of curcumin in non-demented adults: A double-blind, placebo-controlled 18-month trial. A. Thromb.Res 2005;115(5):417-426. Fiala, M., Liu, P. T., Espinosa-Jeffrey, A., Rosenthal, M. J., Bernard, G., Ringman, J. M., Sayre, J., Zhang, L., Zaghi, J., Dejbakhsh, S., Chiang, B., Hui, J., Mahanian, M., Baghaee, A., Hong, P., and Cashman, J. Innate immunity and transcription of MGAT-III and Toll-like receptors in Alzheimer's disease patients are improved by bisdemethoxycurcumin. View abstract. Fundam.Clin Pharmacol 2008;22(4):417-427. Efficacy and safety of curcumin and its combination Yeon, K. Y., Kim, S. A., Kim, Y. H., Lee, M. K., Ahn, D. K., Kim, H. J., Kim, J. S., Jung, S. J., and Oh, S. B. Curcumin produces an antihyperalgesic effect via antagonism of TRPV1. Patumraj, S., Wongeakin, N., Sridulyakul, P., Jariyapongskul, A., Futrakul, N., and Bunnag, S. Combined effects of curcumin and vitamin C to protect endothelial dysfunction in the iris tissue of STZ-induced diabetic rats. 2017;32:88-96. Sharma RA, McLelland HR, Hill KA, et al. View abstract. View abstract. Mol.Cell Biochem. Ramirez-Tortosa, M. C., Ramirez-Tortosa, C. L., Mesa, M. D., Granados, S., Gil, A., and Quiles, J. L. Curcumin ameliorates rabbits's steatohepatitis via respiratory chain, oxidative stress, and TNF-alpha. Neuroscience 6-9-2010; View abstract. 2010;28(1):74-82. People who use Spice a lot may have withdrawal symptoms if they try to quit. Frautschy, S. A., Hu, W., Kim, P., Miller, S. A., Chu, T., Harris-White, M. E., and Cole, G. M. Phenolic anti-inflammatory antioxidant reversal of Abeta-induced cognitive deficits and neuropathology. Lang A, Salomon N, Wu JC, et al. Cancer Res. 2008;9(4):243-250. Br.J Pharmacol 2000;131(2):169-172. J Food Prot. Ital.J Biochem. Pain after surgery. View abstract. View abstract. Mol Nutr Food Res. Am.J Respir.Cell Mol.Biol. Goh, C. L. and Ng, S. K. Allergic contact dermatitis to Curcuma longa (turmeric). 2009;47(10):902-908. Comparison of stratum corneum penetration and localization of a lipophilic model drug applied in an o/w microemulsion and an amphiphilic cream. Rai, D., Singh, J. K., Roy, N., and Panda, D. Curcumin inhibits FtsZ assembly: an attractive mechanism for its antibacterial activity. View abstract. Funk, J. L., Frye, J. This is a United States Government, Drug Enforcement Administration (DEA) website. Singh A, Sridhar R, Shrihatti R, Mandloy A. View abstract. J Crohns Colitis 2014;8(3):208-14. View abstract. Some research shows that taking turmeric by mouth four times daily for 7 days might help improve an upset stomach. View abstract. J Altern.Complement Med. View abstract. Indian spice turmeric Delays and Mitigates radiation-induced oral mucositis in patients with Alzheimer disease ( letter.... 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